Quantitative computed tomography (QCT) and histopathology were used to assess the effects of large single doses of x irradiation on the normal canine brain. Measurable changes demonstrated by QCT included increased contrast enhancement and enlargement of the lateral ventricles, which were observed prior to any clinical signs. The results suggest that QCT methods are effective in the noninvasive evaluation of radiation-induced brain injury.
The authors describe a low-cost CT scanner integrated with a radiotherapy simulator and designed for treatment planning. The standard rotational gantry and x-ray tube of the simulator are used with a multiwire xenon lonization chamber and simple current-proportional readout system to measure patient attenuation, avoiding problems associated with diagnostic CT scanners in treatment planning. Although design constraints limit performance, software compensation techniques have reduced artifacts and given satisfactory images.
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