The anterior inferior cerebellar artery of guinea pigs was occluded, thereby interrupting the blood supply to the cochlea. Durations of occlusion ranged from ! through 60 min. Cochlear microphonics, summating potential, action potential, and endocochlear potential were recorded before, during, and subsequent to occlusion. The differential effect of anoxia on the various potentials was observed, as well as the appearance of the large negative dc potential in scala media as anoxia progressed. For the brief occlusion durations, the amplitudes of all potentials except cochlear microphonics became greater than normal soon after the blood supply returned. Even for the longer anoxic intervals, the summating potential and the endocochlear potential exhibited supernormality during the recovery process.
Pregnant guinea pigs were exposed to loom room noise at 115 dB A for 7.5 hr/day for various periods during the last one-third of pregnancy. When the hearing of their offspring was tested by auditory brain stem-evoked response techniques at 6-dB intervals, peak IV latencies of exposed pups were found to be significantly longer than those of otherwise similar control pups. The latency differences corresponded to a 5-dB increase in stimulus at medium stimulus levels and 10-12 dB near threshold. The results indicate that it is possible for noise-induced loss to occur in utero in mammals whose auditory maturation process is complete, or nearly so, before birth.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.