Due to the emergence of multidrug-resistant TB (MDR-TB) and extensively drug resistant (XDR) TB, the disease becomes a major health security threat globally2. In order to eliminate DRTB there is an urgent need of novel molecules which are very effective with lesser side effects. Hence this research work focused to work on synthesis and biological evaluation of benzothiazole, indole and imidazole derivatives as anti tubercular agents. Benzothiazole, indole and imidazole moieties were designed and docked against glutamine synthetase (PDB ID-3ZXR) using Autodock®tools software. Compounds with minimum binding energy were selected and screened for in silico toxicity prediction using osiris® software and in silico drug likeness prediction by using molinspiration® software. The compounds were synthesized and characterized by IR, 1H NMR and LC-MS. Anti-tubercular activity was evaluated by Microplate Alamar Blue Assay (MABA) method. Among the synthesized compounds, indole derivatives and imidazole derivatives was found to be active at micro gram level.
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