SummaryIn experiments on rabbits it was shown by means of interruption and reestablishment of hepatic and renal circulation that these organs play an essential role in the regulation of the fibrinolytic system of the circulating blood. The kidneys are the source of the plasminogen activator secreted in the blood whereas the liver is responsible for the inactivation of the fibrinolytic system.
SummaryIt was found that the activation of the FSF by thrombin in the presence of calcium ions takes place with a transitory increase of additional SH groups in the FSF.The activation of the FSF and the loss of its activity in the conversion of fibrin polymer to desmofibrin occurs simultaneously with the increase and decrease of additional SH groups.It is considered that in the transition of fibrin polymer to desmofibrin, the disulphide bonds exchange mechanism is involved, if not as a final reaction, at least as a phase in that mechanism.
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