Acute systemic toxoplasmosis was diagnosed in a 4-5-year-old, male, Domestic Short Hair cat, which had been on cyclosporine A immunomodulatory therapy for feline atopy, over an 8-month period. Cyclosporin A (CsA) has shown promising results as a immunosuppressive agent in the cat for the treatment of eosinophilic plaque and granulomas, allergic cervico-facial pruritus, feline atopy and other immune-mediated dermatoses. However, inhibition of T-lymphocyte function by CsA is believed to have predisposed this cat to the development of a newly acquired, acute Toxoplasma gondii infection, as characterized by severe hepatic and pancreatic pathology in conjunction with the heavy parasite load demonstrated on immunohistochemical (IHC) stains for T. gondii. Cats on CsA therapy appear to be at risk of developing fatal systemic toxoplasmosis.
Epidermotropic cutaneous T-cell lymphoma was diagnosed in six Syrian hamsters (Mesocricetus auratus) with a generalised dermatosis characterised by pruritus, alopecia and exfoliative erythroderma. Plaques and nodules were evident in one animal. Clinical and histopathological findings were suggestive of mycosis fungoides and electron microscopical investigations in one case were supportive. Immuno-histochemical stains for CD3 antigen were strongly positive in all cases.
Three cats with upper respiratory tract obstruction due to laryngeal inflammation are presented. Cervical radiography showed the presence of a soft tissue mass in the laryngeal region in all cases, and laryngoscopy allowed direct visualization of a mass associated with the larynx. Laryngeal samples were obtained by a combination of fine needle aspiration, cutting biopsy forceps, by ventral laryngotomy, and at post-mortem. Histopathology of the laryngeal samples showed the presence of a predominantly granulomatous inflammation, with macrophage and lymphocyte infiltration. One case was euthanased due to severe dyspnoea. The remaining two cases underwent combined medical (corticosteroid and antibiotic) and surgical (permanent tracheostomy or excision of laryngeal tissue by ventral laryngotomy) treatment. One case died of an undetermined cause 15 weeks after surgery while the other case remains clinically well 20 months after diagnosis. Recognition of the existence of granulomatous laryngitis is important as clinical signs and radiographic findings are indistinguishable from laryngeal neoplasia.
The clinicopathological features of tonsillar polyps in eight dogs are described. They occurred in aged animals (mean 12.5 years) and caused gagging and retching in two. In the other six the polyps were an incidental finding during anaesthesia for unrelated surgical procedures.
Seven of the polyps were considered to be of inflammatory origin, consisting of a fibrous tissue core containing dilated lymphatics and veins and a variable lymphocytic component. The eighth had microscopic features suggestive of a developmental vascular anomaly (hamartoma).
of a large number of Caryospora oocysts in the faeces and, finally, the lack of any finding associated with any other disease, suggests that Caryospora species was responsible for the death of the snowy owl. References BAXBY, P., BLUNDELL, N. & HART, C. A. (I1984) The development and performance of a simple, sensitive method for the detection of Cryptosporiditm oocysts in faeces. Journial ofHygiene 93, 317-323 CAWTHORN, R. J. & STOCKDALE, P. H. G. (1981) Description of Eimeria btibonis sp n (Protozoa: Eimeriidae) and Caryospora btubonis sp n (Protozoa: Eimeriidae) in the great horned owl, Buibo virgitnianus (Gmelin), of Sascatchewan. Caniadian Jotirtnal ofZoology 59, 170-173
This report describes clinical, histological and post‐mortem findings in a cat, that are similar to necrolytic migratory erythema in humans and to metabolic epidermal necrosis in dogs.
Resumen Este articulo describe los hallazgos clinicos, histopatológicos y post mortem en un gato, similares a Eritema Necrolitico Migratorio en la especie humana y a Necrosis Epidérmica Metabólica en el perro. [Patel, A., Whitbread, J., McNeil. P. A case of metabolic epidermal necrosis in a cat. (Un caso de necrosis epidérmica en un gato.) Veterinary Dermatology 1996; 7: 221–226.]
Résumé Ce cas décrit les lésions cliniques, histopathologiques et nécropsiques chez un chat, évoquant l'érythème nécrolytique migrant de l'homme et la nécrose épidermique métabolique du chien. [Patel, A., Whitbread, J., McNeil. P. A case of metabolic epidermal necrosis in a cat. (Un cas de nécrose épidermique métabolique chez un chat.) Veterinary Dermatology 1996; 7: 221–226.]
Zusammenfassung Dieser Bericht beschreibt klinische, histopathologische und Sektionsbefunde bei einer Katze, die dem hekrolytischen migratorischen Erythem beim Menschen und der stoffwechselbedingten epidermalen Nekrose beim Hund ähneln. [Patel, A., Whitbread, J., McNeil. P. A case of metabolic epidermal necrosis in a cat. (Ein Fall von stoffwechselbedingter epidermaler nekrose bei der Katze) Veterinary Dermatology 1996; 7: 221–226.]
Objective—To determine clinical findings, cytologic
and histologic characteristics of salivary glands, and
response to treatment with phenobarbital in dogs
with clinical signs typical of sialadenosis.
Design—Prospective study.
Animals—13 dogs with enlarged salivary glands.
Procedure—Data were collected from dogs with clinical
signs attributable to enlarged salivary glands.
Salivary gland biopsy and cytologic specimens were
examined. Dogs were treated with phenobarbital and
monitored for response to treatment.
Results—Clinical signs commonly associated with
sialadenosis included retching and gulping. Substantial
cellular changes were not detected by histologic
or cytologic examination of enlarged salivary
glands. Response to treatment with phenobarbital
was rapid, although most dogs required continuous
treatment to prevent recurrence of clinical signs.
Conclusions and Clinical Relevance—Sialadenosis
is a condition of unknown cause that may have been
underdiagnosed in dogs. Criteria for diagnosis include
typical clinical signs, enlarged salivary glands, and lack
of substantial microscopic lesions. Response to treatment
with phenobarbital is rapid. (J Am Vet Med
Assoc 2000;216:872–874)
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