The use of variation in metabolism to predict genetic merit for milk production was studied using 42 Friesian calves: 11 ♀♀, 10 ♂♂ were the offspring of four bulls with high (H), and 11 ♀♀, 10 ♂♂ of four with low (L) improved contemporary comparison (ICC) values (mean = + 402 kg and − 276 kg respectively). The animals were 14 or 15 weeks of age at the start of the study and treated similarly throughout.Blood samples were collected: I—in relation to feeding; II—at set intervals; III—during a 44-h fast; and IV—following the sudden introduction of an energy metabolite (sodium propionate), and then refeeding. Plasma concentrations of β-hydroxybutyrate, glucose, urea, free fatty acids, total proteins and albumin were measured in all samples.Blood characteristics apparently differed among animals, particularly protein and urea (repeatability 0·74 and 0·62 respectively).The progeny of high ICC bulls had lower levels of urea during fasting (H = 4·70, L = 5·62P< 0·05) but higher levels of free fatty acids (H = 578, L = 492 μ equivalents/l;P< 0·05). There was a small difference in total protein (H = 69·7, L = 66·8 g/l,P< 0·05) but the other metabolites showed no significant ICC group difference.In general, sex of the animal did not influence the metabolites.Results suggest that calves with different potentials for milk production vary in aspects of energy and nitrogen metabolism; the possibility of using these as criteria for genetic selection for milk production is discussed.

Insulin, thyroxine and tri-iodothyronine concentrations were measured in samples of blood from 175 Friesian bulls, aged between 2 and 7 years, which were being progeny-tested for milk production. Least squares regression coefficients were estimated for these hormone levels on time of day and time after feed at sampling and age of bull. Correlations between hormone levels and Improved Contemporary Comparisons of the bull, a measure of his daughters' milk production, did not differ significantly from zero, suggesting that simple spot estimates of levels of these hormones in bulls would not supply useful predictors of daughters' production.

1983). Physiological attributes as possible selection criteria for milk production 3. Plasma hormone concentrations and metabolite and hormonal responses to changes in energy equilibrium. Request Permissions : Click here Downloaded from http://journals.cambridge.org/ASC, IP address: 205.175.97.198 on 05 Apr 2015 Arum. Prod. litf. J7: 165-178 (*K)3-.V6l/83/23010165$()2'H0 ABSTRACT Plasma hormone concentrations and metabolite responses to changes in energy equilibrium were measured in experiments designed to compare a) Hereford x Friesian with Friesian calves and b)Friesian calves sired by bulls with a high level of Improved Contemporary Comparison with those sired by bulls of a low level. The concentration of thyroxine and triiodothyronine tended to be greater in calves of higher dairy merit. The concentration of growth hormone was largely unrelated to dairy merit in the circumstances studied. The concentration of insulin was greater in Hereford x Friesian than in Friesian calves following feeding and following the injection of propionate. Responses to the injection of insulin and of growth hormone (as measured by changes in the plasma concentration of urea nitrogen, free fatty acids, glucose or the other hormone) were little affected by the level of Improved Contemporary Comparison of a calfs sire.It was concluded that the thyroid system and the response of insulin to perturbation of energy balance may provide criteria of genetic merit for milk production which are neither age-nor sex-limited.

British Friesian and Jersey cows were mated either to high contemporary comparison (CC) bulls for their first pregnancy and to low bulls for their second pregnancy, or vice versa. Sixteen proven bulls were used, four ‘high’ and four ‘low’ in each breed. Least squares analysis of data on 175 lactations gave estimates of each bull's effect on his mates' milk yield in the ensuing lactation, but there were no significant differences between bulls for this ‘mate effect’. The high bulls tended to depress their mates' milk yield in the subsequent lactation and the low bulls tended to increase it. Weighted regressions of the ‘mate effect’ on breeding value had negative slopes for both breeds and for first and second lactations, separately or combined. The high CC bulls appeared to depress their mates' milk yield by at least 10% of the amount by which their daughters' yield was expected to increase.