A design for an X-band rf photoinjector that was developed jointly by SLAC National Accelerator Laboratory (SLAC) and Lawrence Livermore National Laboratory (LLNL) is presented. The photoinjector is based around a 5.59 cell rf gun that has state-of-the-art features including: elliptical contoured irises; improved mode separation; an optimized initial half cell length; a racetrack input coupler; and coupling that balances pulsed heating with cavity fill time. Radio-frequency and beam dynamics modeling have been done using a combination of codes including PARMELA, HFSS, IMPACT-T, ASTRA, and the ACE3P suite of codes developed at SLAC. The impact of lower gradient operation, magnet misalignment, solenoid multipole errors, beam offset, mode beating, wakefields, and beam line symmetry have been analyzed and are described. Fabrication and testing plans at both LLNL and SLAC are discussed.

Relativistic klystrons are being developed as an rf power source for high gradient accelerators applications which include large linear electronpositron colliders, compact accelerators, and FEL sources. In a relativistic klystron two-beam accelerator (RK-TBA), the drive beam passes through a large number of rf output structures. High conversion efficiency of electron beam energy to rf energy can be achieved in two-beam accelerators using reacceleration of the bunched drive beam. We have conducted experiments which studied rf power extraction in an RK-TBA and have prepared a demonstration in which a modulated beam's energy is boosted as it passes through induction accelerator cells.

The DARHT-II linear-induction accelerator has been successfully operated at 1.2-1.3 kA and 12.5-12.7 MeV to demonstrate the production and acceleration of an electron beam. Beam pulse lengths for these experiments were varied from 0.5 s to 1.2 s full-width half-maximum. A low-frequency inductance-capacitance (LC ) oscillation of diode voltage and current resulted in an oscillation of the beam position through interaction with an accidental (static) magnetic dipole in the diode region. There was no growth in the amplitude of this oscillation after propagating more than 44 m through the accelerator, and there was no loss of beam current that could be measured. The results of these initial experiments are presented in this paper.

This work describes the process development and manufacture of early-stage clinical supplies of a hepatoselective glucokinase activator, a potential therapy for type 2 diabetes mellitus. Critical issues centered on challenges associated with the synthesis of intermediates and API bearing a particularly racemization-prone α-aryl carboxylate functionality. In particular, a T3P-mediated amidation process was optimized for the coupling of a racemization-prone acid substrate and a relatively nonnucleophilic amine. Furthermore, an unusually hydrolytically-labile amide in the API also complicated the synthesis and isolation of drug substance. The evolution of the process over multiple campaigns is presented, resulting in the preparation of over 110 kg of glucokinase activator.

In heavy-ion inertial-confinement fusion systems, intense beams of ions must be transported from the exit of the final-focus magnet system through the fusion chamber to hit spots on the target with radii of about 2 mm. For the heavy-ion-fusion power-plant scenarios presently favored in the U.S., a substantial fraction of the ion-beam space charge must be neutralized during this final transport. The most effective neutralization technique found in numerical simulations is to pass each beam through a low-density plasma after the final focusing. To provide quantitative comparisons of these theoretical predictions with experiment, the Virtual National Laboratory for Heavy Ion Fusion has completed the construction and has begun experimentation with the neutralized-transport experiment. The experiment consists of three main sections, each with its own physics issues. The injector is designed to generate a very high-brightness, space-charge-dominated potassium beam, while still allowing variable perveance by a beam aperturing technique. The magnetic-focusing section, consisting of four pulsed quadrupoles, permits the study of magnet tuning, as well as the effects of phase-space dilution due to higher-order nonlinear fields. In the final section, the converging ion beam exiting the magnetic section is transported through a drift region with plasma sources for beam neutralization, and the final spot size is measured under various conditions of neutralization. In this paper, we discuss the design and characterization of the three sections in detail and present initial results from the experiment.