Abstract:The purpose of this paper is to present approaches of Medicinal Chemistry to drugs design in an objective way. In this case, it was considered the changes of paradigms and the acquisition of new technologies that have involved this scientific area throughout the time. Analog Design, Systematic Screening, Rational Drug Design and the Exploitation of Biologic Information were here presented by classic examples of literature concerning innovative drugs. These approaches could serve as examples to design new drug prototypes, in special for several diseases that currently have no appropriate treatment.
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