A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed.
Synthesis and Transformations of 4-Substituted 2-Aminothiazoles. -The synthesis of a range of 4-substituted 2-aminothiazoles (III) (5 examples) by simple condensation reactions of thiourea with ketone derivatives and some reactions on their exocyclic N2-atom are given. -(IBATULLIN, U. G.; PETRUSHINA, T. F.; LEITIS, L. YA.; MINIBAEV, I. Z.; LOGVIN, B. O.; Khim. Geterotsikl. Soedin. (1993) 5, 715-718; Bashkirskii gos. univ., Ufa 450074, Russia; RU)
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