Abstract:Background: Heparin and low molecular weight heparin are the most frequently used antithromboembolic drugs in fractures. Objectives: We aimed to compare the effects of heparin and enoxaparin, which are used as standard treatment, on viability in degloving injuries. Methods: Thirty rats were used in the study. Three groups were composed including 10 rats in each group. Degloving injuries were formed in the tails of the rats. Enoxaparin was injected subcutaneously to the rats in group 1. Standard heparin was injected subcutaneously to the rats in group 2. Serum physiologic solution was injected subcutaneously to the rats in group 3. The experiment was ended on day 15. The tails of the rats were evaluated clinically and histopathologically.Results: There was a statistically signifi cant difference in the clinical results (p < 0.05). There was a statistically signifi cant difference in the histopathological results (p < 0.05). Conclusions:We encountered positive effects of both heparin and enoxaparin on the treatment of degloving injuries in this experimental study. However, the fi ndings of this study should be supported and improved by new experimental and especially clinical studies (Fig. 3 "Degloving" is a soft tissue injury defi ned as traumatic avulsion of the skin and subcutaneous tissue, together with the underlying deep fascia. Skin includes a dermal vascular plexus. A break in the dermal vascular plexus is formed due to the separation of vessels from the skin in degloving type of injury. Skin necrosis can be seen as a result.De-gloving occurs frequently due to shear forces as a result of contact of the extremity with circling objects forming a high speed of friction, such as car wheels or motorcycle accidents. Degloving injuries are divided into two groups as open and closed injuries (1). Skin is generally open in degloving injury due to shear forces.Open de-gloving injury was fi rst defi ned by Slack (2) in 1952. Slack evaluated the association of these injuries with wheel injuries and defi ned these injuries as friction injuries.Slack, in addition, proved in his study that the skin necrosis was due to loss of muscle support of subcutaneous tissue in secondary sepsis, and delayed skin gangrene. Closed degloving injury may occur when the underlying deep fascia raises the subcutaneous tissue without superfi cial tears (1). Most frequently seen degloving injuries are reported to be in the leg in 31.6 %, in femur in 21.1 %, in pelvis in 21.1 %, and in the feet in 13.2 % of cases (3).Data related to the results of treatment of degloving injuries are scarce. Two points have to be taken into account for the results: these are cosmetic results and extremity function.Standard heparin acts by binding to an inhibitor enzyme, antithrombin III. Lower molecular heparin compounds are obtained by chemical and enzymatic depolimerization of heparin (4). LMWH lowers the risk of bleeding by minimally effecting on aPTT; while, heparin increases the bleeding risk by lengthening the coagulation time (aPTT, TT). We eval...
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