Samuel Goldflam was an eminent physician and social activist, an internationally recognised neurologist and internist, one of the pillars of Polish neurology who made a great contribution to the development of neurological semiology. Goldflam's name is related to many symptoms and diseases, both in internal medicine and in neurology. It is encountered in present-day textbooks and routinely entered in the context of kidney percussion in patients' medical records.
Plasma cortisol concentration was measured 4 times in a 24 h period in 4 groups of patients. Thirty of them complained of pain with different circadian rhythmicity (nocturnal pain, diurnal pain, continuous pain) and 10 were pain-free and served as a control group. The mean plasma cortisol concentration was significantly higher in pain patients as compared with healthy, pain-free subjects at the time of the highest pain intensity. There is a positive correlation between the intensity of pain and increased plasma cortisol level and this disagrees with previous reports of a relationship of pain and lower blood cortisol levels.
The significance of these changes remains unclear. No data have been published until now concerning the presence of any brain lesions in patients with familial narcolepsy.
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