The susceptibility of 72 isolates of Candida albicans to the antimicrobial honey distillate fraction (HY-1) and several antimycotic agents is presented. All the isolates were sensitive to HY-1, H-115 and Jadit, while about 10% of the isolates were variably resistant to nystatin, miconazole nitrate and clotrimazole. The nystatin, miconazole nitrate and clotrimazole resistant isolates were inhibited by HY-1.

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The in vitro activity of ceftriaxone, a cephalosporin derivative, recently introduced in Nigeria was compared with the activities of other related β-lactam antibiotics such as cefotaxime, cefuroxime, cephaloridine, cloxacillin/ampicillin and ampicillin against 530 local clinical isolates of gram-negative and gram-positive bacteria. The spectra of activity and potency of ceftriaxone and cefotaxime were generally similar against the Enterobacteriaceae, Pseudomonas aeruginosa, Serratia spp., Streptococcus spp. and Neisseria gonorrhoeae, but less active against Staphylococcus aureus and Staphylococcus epidermidis when compared to cefotaxime. All the other β-lactam antibiotics tested were less active than ceftriaxone. The action of ceftriaxone was bactericidal and the minimum inhibitory concentration values observed with R-plasmid β-lactamase mediated resistant Escherichia coli, Klebsiella spp., Proteus spp. and N. gonorrhoeae strains did not exceed the maximum value obtained with the β-lactamase-negative strains.

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Die Kondensation des Isoflavyliumsalzes (I) mit dem Diarylpropen (IIa) führt zu dem Isoflaven (IIIa) (Hauptprodukt) und dem Benzoxanthen (IVa) (dem 9‐Benzylether von Dihydroper‐O‐methylsantarubin).