The accurate experimental determination of pharmaceutical compound solubilities at various temperature and pressure ranges in supercritical carbon dioxide (ScCO2) is a challenging and time‐consuming task. Therefore, prediction or correlations of solute solubilities are essential for implementation of ScCO2 technologies to pharmaceutical industries. Solubilities of 41 pharmaceutical compounds in ScCO2 are correlated by an empirical model, which is developed based on the degree of freedom analysis. Its correlating ability is compared with existing solubility models elaborated by other authors and evaluated in terms of global mean absolute relative deviation, sum of squares due to error, root mean square deviation, R2, and Adj. R2. The proposed model is found to correlate better than existing models.
SYNOPSIS
Several poly (arylamino-quinone) s ( PAAQs) were prepared by the conventional solution polymerization of p -benzoquinone with various aromatic diamines in tetrahydrofuran.Polymers prepared by this method were found to be more soluble in many organic solvents compared to the PAAQs prepared by other reported methods. The poly( arylamino-quinone)s were obtained in 82.3-94.5% yield and had inherent viscosities in the range of 0.073-0.251 dL/g. Among the PAAQs, the polymer prepared from p -benzoquinone and 1,3-bis ( 3-aminophenoxy ) benzene ( APB ) had demonstrated exceptionally good solubility and thermal stability.
Polyimides containing cardo units are known for their excellent solubility and thermal stability.',' It is found that the thermal stability of the polymers increases markedly with decreasing number of single connecting groups in the polymer backbone, viz., introduction of double-strand heterocyclic units instead of single-strand units? The polymers containing phenoxaphasphine units belong to this type, where an open-chain diphenyl ether linkage is replaced by a double-strand structure. Reported here are the preparation, characterization, and properties of cardopolyimides (CPIs) prepared by two-step solution polycondensation method from 2,3,7,8-
SYNOPSISIn order to study the effect of the presence of phenyl groups in poly(amino-quinone) ( PAQ) polymers, several novel poly (amino-2-phenylbenzoquinone ) ( PhPAQ ) polymers have been prepared from 2-phenylbenzoquinone and aliphatic diamines, such as 1,6-diaminohexane, l&diaminooctane, 1,12-diaminododecane, and 1,4-diaminocyclohexane. Prior to the polymerization, 2-phenylbenzoquinone was generated in situ from 2-phenylhydroquinone in the presence of calcium hypochlorite as the oxidizing agent in dichloromethane. All of the polymers synthesized have been characterized with respect to their corresponding model compounds. It was also found that unlike their analogous PAQ polymers, PhPAQ polymers were highly soluble in many common organic solvents because of the presence of phenyl groups in their polymer backbone.
SynopsisSeveral new cardopolyamides containing phenoxathiin-10,lO-dioxide and phenoxaphosphine units were prepared by condensing 3,3-bis(4-aminophenyl)-phthalide (PDA), 9,9-bis(4-aminopheny1)fluorene (FDA), and 9,9-bis(4-aminophenyl)-lO-anthrone (ADA) with 2,8-dichloroformylphenoxathiin-l0,lO-dioxide (PDC) and 2,8-dichloroformyl-l0-phenylphenoxaphosphine-10oxide (PPDC) in DMAc. A low temperature solution polycondensation technique was employed throughout. The cardopolyamides were obtained in 80-92% yield and showed inherent viscosities in the range 0.41-0.6 dL/g. All the polymers were characterized by IR spectra, density, solubility, crystallinity, and thermal analysis. C h m . , 11, 45 (1974).
(1981).
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