In the current article, an experimental investigation has been implemented of flow and heat transfer characteristics in a parabolic trough solar collector (PTSC) using both nano-fluids and artificial neural networks modeling. Water was used as a standard working fluid in order to compare with two different types of nano-fluid namely, nano-CuO /H2O and nano-TiO2/ H2O, both with a volume concentration of 0.02. The performance of the PTSC system was evaluated using three main indicators: outlet water temperature, useful energy and thermal efficiency under the influence of mass flowrate ranging from 30 to 80 Lt/hr. In parallel, an artificial neural network (ANN) has been proposed to predict the thermal efficiency of PTSC depending on the experimental results. An Artificial Neural Network (ANN) model consists of four inputs, one output parameter and two hidden layers, two neural network models (4-2-2-1) and (4-9-9-1) were built. The experimental results show that CuO/ H2O and TiO2/H2O have higher thermal performance than water. Overall, it was verified that the maximum increase in thermal efficiency of TiO2/H2O and CuO/H2O compared to water was 7.12% and 19.2%, respectively. On the other hand, the results of the model 4-9-9-1 of ANN provide a higher reliability and accuracy for predicting the Thermal efficiency than the model 4-2-2-1. The results revealed that the agreement in the thermal efficiency between the ANN analysis and the experimental results about of 91% and RMSE 3.951 for 4-9-9-1 and 86% and RMSE 5.278 for 4-2-21.
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