685were sick in the early neonatal period (groups 10 and 12-19). It is impossible to characterize the embryotoxic effect of sera of newborns depending on the mother's disease because of the relatively small number of observations and the difficulties encountered in differentiating the diagnostics of a vast array of pathologies. However, it should be noted that the embryotoxic effect is considerably potentiated by hypoxia. The sera of 4 newborns after prenatal hypoxia (groups 14-17, as evidenced by the presence of meconium in the amniotic fluid) induced death of mouse embryos in 100, 100, 73, and 23% of cases, respectively. A 100% embryolethal effect was seen in the serum of a newborn after hemolytic (ABO) disease (group 18). This effect may be due to the similarity of the ABO system of humans and mice.Thus, our results indicate that in vitro culture of preimplantation mouse embryos can be used for the evaluation of embryotoxicity of sera from newborns.
REFERENCES1. T. V. Avaliard, N. A. Chebotar', T. V. Ignat'eva, et al., Zh. Evol. J3iokhim. Fiziol., No I, 126-129 (1992). 2. N. I. Gabrielyan and V. I. Lipatova, Lab. Delo, N o _ 3, 128-140 (1984). 3. G. V. Glinskii, V. G. Nikolaev, A. V. Ivanova, et al., Ekxp. Onkol., 2, No-1, 68-71 (1980). 4. N. A. Chebotar', V. G. Vakhaflovskii, T. V. Ignat 'eva, et al., Okhr. Mater., 37, No 4-5, 36 (1992). 5. Zh. I. Shelipova and S. O. Balyakin, Lab. Delo, No-9, 546-548 (1984 bution to the development of the organism's response to stress. The system of physiological regulation of RZ is not clear either [14]. The aim of our research was to study changes in the activity and physiological regulation of the adrenocortical RZ under the effect of stress.
MATERIALS AND METHODSExperiments were carried out with male Wistar rats weighing about 200 g. The animals were castrated