Successful treatment of acne vulgaris (AV) can impact patient’s quality of life. AV treatment outcome is associated with the patient adherence. The aim of this study was to know the association between acne vulgaris and adherence among medical students of Universitas Riau. The samples were students with AV according to inclusion criteria as 39 respondents. In this study, respondents got check the grade of the AV according to Lehmann classification, the adherence was measured using the translation and modification of Elaboration d’un outil d’evaluation de l’observance des traitements medicamenteux (ECOB) Questionnaire that has been tested. In this study, mild AV was found among 69.23% of the respondents as the most AV grade found among the respondents. Adherence rate was found to be poor as 53.85% of the respondents have poor adherence to medication. Statistic test showed there was a correlation between AV grade and adherence with the p-value of 0,006 (p<0,05).
ABSTRAKAkne vulgaris merupakan penyakit radang kronik folikel pilosebasea yang banyak terjadi pada remaja. Manifestasi klinis berupa komedo, papul, pustul, nodus dan kista. Akne vulgaris merupakan penyakit yang dipengaruhi oleh banyak faktor, yaitu faktor genetik, lingkungan, hormon, stres, makanan, trauma, kosmetik, obat, serta defisiensi mineral misalnya zink. Kadar zink berpengaruh pada proses inflamasi, aktivitas Propionibacterium acnes, hiperproliferasi unit pilosebasea, dan produksi sebum yang merupakan patogenesis akne vulgaris. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar zink plasma dengan derajat akne vulgaris pada mahasiswa Fakultas Kedokteran Universitas Riau. Desain penelitian ini adalah potong lintang analitik. Subjek penelitian ini adalah mahasiswa Fakultas Kedokteran Universitas Riau berjumlah 35 orang berusia > 18 tahun. Data yang diperoleh dianalisis secara statistik menggunakan uji korelasi Spearman. Hasil uji statistik kadar zink plasma dengan derajat akne vulgaris menunjukkan hubungan bermakna (p=0,003) dengan kekuatan korelasi sedang (r=-0,490) antara kadar zink plasma dengan derajat akne vulgaris. Hasil ini menunjukkan bahwa semakin rendah kadar zink plasma maka semakin berat derajat akne vulgaris yang dialami. ABSTRACTAcne vulgaris is a chronic inflammatory disease of the pilosebacea follicle mostly affecting adolescents. Clinical manifestations are comedones, papules, pustules, nodes and cysts. Acne vulgaris is influenced by many factors, such as genetic, environments, hormonal, stress, diet, cosmetics, drugs, and zinc deficiency. Level of zinc have an effect on inflammatory process, Propionibacterium acnes activity, pilosebacea unit hyperproliferation, and sebum production. The aim of this study was to determine the correlation of plasma zinc levels with acne vulgaris severity of medical students at Faculty of Medicine, Universitas Riau. The design of this study was analytic observational in the form of cross sectional study. Subject of this research is medical students at Faculty of Medicine, Universitas Riau that consist of 35 students who were aged > 18 years. Result was analyzed statistically using Spearman correlation test. Statistically plasma zinc levels with acne vulgaris severity showed significant correlation (p=0.003) with the strength of correlation is moderate (r=-0.490). This study showed that the plasma zinc level negatively correlated with the severity of acne vulgaris.
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