Germinated waxy wheat had a better nutritional composition, such as higher dietary fibre, free amino acid and total phenolic compound contents, than ungerminated waxy wheat. Therefore germinated waxy wheat should be used to improve the nutritional quality of cereal-based products.
The synthesis of 2-aminobenzenesulfonamide-containing cyclononyne (ABSACN), starting from 2-nitrobenzenesulfonamide and but-2-yne-1,4-diol via Mitsunobu and Nicholas reactions, is described for the development of an adjustable alkyne reagent in click reactions. In a strain-promoted azide-alkyne cycloaddition (SPAAC) reaction, the reactivity of the alkyne is controlled by introducing various N-functionalities. The structure-reactivity relationship is found to be influenced by a transannular hydrogen bond between amino and sulfonyl groups.
(3-Mercaptopropyl)trimethoxysilane was employed as a chain transfer for the polymerization of N-isopropylacrylamide (NIPAM) and N,N-dimethylacrylamide (DMAA) under UV irradiation to obtain the corresponding polymers having methoxysilyl end group. By the condensation reaction of such macrosilane coupling reagents under basic or acidic conditions, the grafted polysilsesquioxanes, which were soluble in usual organic solvents, were formed without gelation. The cocondensation of the macrosilane coupling reagents enabled the preparation of the grafted polysilsesquioxane, in which poly(NIPAM) and poly(DMAA) were introduced respectively into the polysilsesquioxane main chain. Such macrosilane coupling reagents and the grafted polysilsesquioxanes showed an amphiphilic property. Furthermore, those containing poly(NIPAM) showed reversible thermoresponsive aggregation in an aqueous solution. In the thermoresponsive phase separation measured by turbidity, no change of aggregation temperature caused by the presence of poly(DMAA) was observed.
2-Aminobenzenesulfonamide-containing cyclononyne (ABSACN), whichi saheterocycle that contains a sultam and strained alkyne group within the same ring, exhibits remarkable chemical reactivity in processes such as pyrrole transformations, Pauson-Khandc yclizations, click reactions, and Mitsunobu condensations. Herein, we introduce the synthesis and reactions of ABSACN, which focus on the sultam and alkyne functional groups, and study the unique characterization of prepared ABSACN derivativesb yN MR and X-ray crystallographic analyses. This work could lead to the efficient production of pharmaceutically relevant multiheterocyclic systemsb yu sing sequential cycloaddition reactions. ABSACN can also serve as ap otentialt emplate for multifunctional clickable alkyne reagents.Scheme1.Chemical transformationso fA BSACN (FG = functional group).[a] Dr.
Scheme2.Preparation of N-alkynylsulfonamidesScheme3.Nitroarenereduction, cobalt complexation, and Nicholas cyclization reaction sequence.Scheme4.Nitroarenereduction of alkyne-cobalt carbonyl complex 27.Scheme5.Formation of maleic anhydride.Scheme6.Liberation of the cobalt complex.Scheme7.Pyrrole transformation.Scheme8.Strain-promotedP auson-Khand cycloaddition.Scheme9.SequentialSPAAC/Mitsunobu cycloaddition.
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