Astounding results from Transformer models on natural language tasks have intrigued the vision community to study their application to computer vision problems. Among their salient benefits, Transformers enable modeling long dependencies between input sequence elements and support parallel processing of sequence as compared to recurrent networks e.g. , Long short-term memory (LSTM). Different from convolutional networks, Transformers require minimal inductive biases for their design and are naturally suited as set-functions. Furthermore, the straightforward design of Transformers allows processing multiple modalities ( e.g. , images, videos, text and speech) using similar processing blocks and demonstrates excellent scalability to very large capacity networks and huge datasets. These strengths have led to exciting progress on a number of vision tasks using Transformer networks. This survey aims to provide a comprehensive overview of the Transformer models in the computer vision discipline. We start with an introduction to fundamental concepts behind the success of Transformers i.e., self-attention, large-scale pre-training, and bidirectional feature encoding. We then cover extensive applications of transformers in vision including popular recognition tasks ( e.g. , image classification, object detection, action recognition, and segmentation), generative modeling, multi-modal tasks ( e.g. , visual-question answering, visual reasoning, and visual grounding), video processing ( e.g. , activity recognition, video forecasting), low-level vision ( e.g. , image super-resolution, image enhancement, and colorization) and 3D analysis ( e.g. , point cloud classification and segmentation). We compare the respective advantages and limitations of popular techniques both in terms of architectural design and their experimental value. Finally, we provide an analysis on open research directions and possible future works. We hope this effort will ignite further interest in the community to solve current challenges towards the application of transformer models in computer vision.

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Figure 1: Imbalance learning with Bayesian uncertainty estimates. (a) We enforce classlevel margin penalty based on class uncertainty. This pushes boundaries further away from rare classes B and C. (b) We also consider sample-level uncertainty that is modeled as a Gaussian distribution. The learned margins consider the confidence level of classifier to re-adjust boundaries (i.e., provide more room to uncertain samples). This improves the generalization ability of the proposed model for imbalanced classes. AbstractLearning unbiased models on imbalanced datasets is a significant challenge. Rare classes tend to get a concentrated representation in the classification space which hampers the generalization of learned boundaries to new test examples. In this paper, we demonstrate that the Bayesian uncertainty estimates directly correlate with the rarity of classes and the difficulty level of individual samples. Subsequently, we present a novel framework for uncertainty based class imbalance learning that follows two key insights: First, classification boundaries should be extended further away from a more uncertain (rare) class to avoid over-fitting and enhance its generalization. Second, each sample should be modeled as a multi-variate Gaussian distribution with a mean vector and a covariance matrix defined by the sample's uncertainty. The learned boundaries should respect not only the individual samples but also their distribution in the feature space. Our proposed approach efficiently utilizes sample and class uncertainty information to learn robust features and more generalizable classifiers. We systematically study the class imbalance problem and derive a novel loss formulation for max-margin learning based on Bayesian uncertainty measure. The proposed method shows significant performance improvements on six benchmark datasets for face verification, attribute prediction, digit/object classification and skin lesion detection.

Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as de facto operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved issues. Specifically, we survey the use of Transformers in medical image segmentation, detection, classification, reconstruction, synthesis, registration, clinical report generation, and other tasks. In particular, for each of these applications, we develop taxonomy, identify application-specific challenges as well as provide insights to solve them, and highlight recent trends. Further, we provide a critical discussion of the field's current state as a whole, including the identification of key challenges, open problems, and outlining promising future directions. We hope this survey will ignite further interest in the community and provide researchers with an up-to-date reference regarding applications of Transformer models in medical imaging. Finally, to cope with the rapid development in this field, we intend to regularly update the relevant latest papers and their open-source implementations at https://github.com/fahadshamshad/awesome-transformers-in-medical-imaging.

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