The aim of cardiovascular nanomedicine- CVN is to reduce off-target toxicity issues with therapeutic selectivity to the
heart .The lipophilic barrier of the cellular membranes should be circumvented to deliver cargo inside the cell. Lipidbased NPs, which show low side effects and greater ability to passively accumulate at tissues with higher vascular permeability (enhanced
permeation rate), have been largely used since the earlier times of cardiovascular nanomedicine-CVN. Polymeric NPs, silica NPs, carbon
nanotubes, polymeric micelles, quantum dots, nanobers and nanocrystals represent other examples of nano-formulations for controlled drug
delivery. NP-loaded drugs are expected to be protected from systemic degradation, show reduced toxicity and immunogenicity, possess
ameliorated pharmacokinetics and increased half-life and exhibit increased bioavailability and precise bio distribution. Nanodrug formulations
are expected to enhance selective delivery to the site of interest and benet from a lower clearance from the body. Nanotechnology represents a
convergent discipline in which the margins separating research areas, such as chemistry, biology, physics, mathematics and engineering become
blurred with the much needed emergence of integrated science as a new discipline.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.