nostril to help spread the ointment. Patients were trained during the first decolonization session, and received the necessary materials and a guide to help them perform the following sessions 4 times a day for 5 days.Follow-up was done on day 1 and then every 2 days until day 7 to assess the efficacy (viral quantification) and safety of the decolonization. Almost all (>95%) of the nasopharyngeal swabs were taken by the same skilled nurse at least 3 hours after the last PI application for quantification of viral RNA using RT-PCR, 3 and viral titer using the dilution limit method on Vero cells and the Spearman-Karber approach with a limit of detection of 10 2.5 tissue culture infectious dose (TCID 50 ) per mL. 4 Changes in viral load over time were compared between study groups using a linear mixed model for repeated measures.
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