occurs.7. Therapeutic desensitization except in the case of plant excitants is rarely accomplished. 8. Recent work with the development of BAL (2,3-dimercaptopropanol) for arsenical and mercurial intoxications indicates that interference with an enzymatic system is responsible for the deleterious effect of these chemicals. Allergy as such is not involved. There is a great tendency to speak of various tissues as the "shock organs." Thus in contact dermatitis it is the epidermis. In the light of recent work by Peters and his co-workers on cutaneous vesicants it is necessary to probe deeper and to consider the physiology and biochemistry of the individual cell, and more particularly the enzymatic systems of the cells involved.The second group of conditions so often considered to be allergic in their causative mechanism are the drug eruptions.The recent and successful use of BAL in the treatment of acute arsenical eruptions as well as those due to gold, bismuth, and mercury compounds makes one feel that perhaps allergy as an etiologic mechanism has been overemphasized.Dr. Louis Tuft, Philadelphia : I get the impression from Dr. Webster's paper that skin tests are of little value in
Clinical experience has not confirmed previous observations that intravenous injection of vitamin C and intramuscular injection of histidine monohydrochloride are useful in the treatment of peripheral ischemia observed in arteriosclerosis obliterans. Clinical experience with intravenous injection of ether has failed to indicate that this method of treatment is of value in improving the peripheral arterial circulation in thrombo-angiitis obliterans and arteriosclerosis obliterans.
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