Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded on carbon nanotubes under near-infrared (NIR) irradiation led to the remarkably enhancement in response towards cancer cells. The dose of metformin has reduced to only 1/280 of typical doses in monotherapy (35: 10 000–30 000 µM) where the realization of metformin in conventional antidiabetic doses for cancer therapies becomes possible. The heat generated from carbon nanotubes upon NIR irradiation has mediated a strong and highly localized hyperthermia-like condition that facilitated the enhancement. Our work highlight the promise of using highly localized heating from carbon nanotubes to intensify the efficacy of metformin for potential cancer therapies.
Reduced graphene oxide (rGO) based chemiresistor gas sensor has received much attention in gas sensing for high sensitivity, room temperature operation, and reversible. Here, for the first time, we present a promising chemiresistor for ammonia gas detection based on tannic acid (TA) functionalized and reduced graphene oxide (rGOTA functionalized). Green reductant of TA plays a major role in both reducing process and enhancing the gas sensing properties ofrGOTA functionalized. Our results showrGOTA functionalizedonly selective to ammonia with excellent respond, recovery, respond time, and recovery times.rGOTA functionalizedelectrical resistance decreases upon exposure to NH3where we postulated that it is due to n-doping by TA and charge transfer betweenrGOTA functionalizedand NH3through hydrogen bonding. Furthermore,rGOTA functionalizedhinders the needs for stimulus for both recovery and respond. The combination of greener sensing material and simplicity in overall sensor design provides a new sight for green reductant approach of rGO based chemiresistor gas sensor.
It is a challenging and application‐oriented goal to achieve the metal/semiconductor separation of large diameter single‐walled carbon nanotubes (SWCNTs) using a dextran‐based gel chromatograph. Herein, a study of the temperature effect on the metal/semiconductor separation of plasma torch SWCNTs through dextran‐based gel chromatograph is conducted. The temperature governs the interaction between SWCNTs and hydrogel, thus enabling the sorting of SWCNTs by electronic type. In addition, the temperature effect enables the metallic (m‐) and semiconducting (sc‐) fraction to be resolved and eluted using a single cosurfactant system, so that the process can be iterated easily. The fractions containing up to 99% of sc‐SWCNTs and 95% of m‐SWCNTs have been obtained after three times of iteration. The iteration process is not only applicable to sc‐SWCNTs and m‐SWCNTs, but also practicable for the cosurfactant system and circumvents additional preparation steps.
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