Moxifloxacin is a widely used topical antibiotic in various bacterial infections of the eye. Its safety and efficacy have been proved by many studies. We report a case of a rare adverse effect following its use. A 10-year-old female who had presented with acute bacterial conjunctivitis in both eyes with no corneal involvement was started on preservative-free 0.5% topical moxifloxacin four times a day. The child developed a severe form of corneal toxicity in both eyes with circumcorneal congestion and corneal edema following its use. The child's visual acuity had dropped from 20/20 to 20/400 in both the eyes. Topical moxifloxacin was discontinued, following which the cornea cleared dramatically and the visual acuity became normal. This case indicates that though rare, topical moxifloxacin can cause severe keratitis and that more studies need to be conducted to evaluate its safety.

Aim: To describe a rare case of Vogt's limbal girdle in a boy with retinitis pigmentosa. Methods: A 13-year-old boy from India presented to us with progressive diminution of vision and nyctalopia for 5 years. On examination, he had the characteristic features of retinitis pigmentosa with the fundus showing disc pallor, bony spicules and arteriolar attenuation. His anterior segment examination showed Vogt's limbal girdle in both eyes. Results: Vogt's limbal girdle is a corneal degeneration usually seen in elderly individuals. This is the first time it is seen in association with retinitis pigmentosa. It has also never been reported at such a young age. Conclusion: We report a rare case where Vogt's limbal girdle was observed in a 13-year-old boy with retinitis pigmentosa. This gives further insight into the pathogenesis of the disease.

Moxifloxacin ist ein sehr gebräuchliches topisches Antibiotikum zur Behandlung verschiedener bakterieller Infektionen des Auges. Seine Sicherheit und Wirksamkeit sind durch zahlreiche Studien belegt. Wir berichten über einen Fall einer seltenen Nebenwirkung seiner Anwendung. Ein 10-jähriges Mädchen, das sich mit akuter bakterieller Konjunktivitis ohne Hornhaut-Beteiligung in beiden Augen vorgestellt hatte, wurde mit Konservierungsmittel-freiem, 0,5%igem, topischem Moxifloxacin 4-mal täglich behandelt. In beiden Augen entwickelte sich nach Beginn der Behandlung eine schwere Hornhaut-Toxizität mit perikornealer Stauung und Hornhaut-Ödem. Die Sehschärfe des Mädchens fiel in beiden Augen von 20/20 auf 20/400 ab. Das topische Moxifloxacin wurde abgesetzt, woraufhin die Hornhaut sich drastisch erholte und die Sehschärfe sich normalisierte. Dieser Fall zeigt, dass topisches Moxifloxacin - wenngleich selten - schwere Keratitis verursachen kann und dass weitere Studien erforderlich sind, um die Sicherheit zu beurteilen.