Background Antigonon leptopus is a medicinal plant its leaves has not been reported for protective effects against cadmium induced hepatorenal toxicity. Cadmium (Cd) is a non-essential toxic metal used in industrial process, causes severe risk to human health with high levels. It is accumulated primarily in liver and kidney. Methods Male Wistar albino rats (200-250 g) were divided into 6 groups (n = 6) and had free access to diet and water. Cadmium chloride (5 mg/kg b.w/day) was administered orally for 21 days and methanolic extract of Antigonon leptopus (ALME) was administered to groups of cadmium treated rats at daily doses of 100, 200 and 400 mg/kg b.w;p.o. for 21 days. At the end, liver and kidney markers along with antioxidant parameters are evaluated. Results The results indicated that, administration of cadmium significantly (p < 0.05) increased the levels liver enzymes in serum and bilirubin levels, decreases in total proteins and albumin; in addition to the levels of uric acid, urea and creatinine were increased in the serum. Glutathione (GSH) levels and the enzyme catalase activities were significantly(p < 0.05) decreased while lipid peroxidation was increased in hepatic and renal tissues of cadmium treated rats. The pre-administration of ALME at all the three test doses, alleviated hepatorenal toxicity in cadmium treated rats, used Silymarin (100 mg/kg) as standard. Moreover, ALME treatment was able to reverse the histopathological changes in liver and kidney tissues, and increased the red blood cells, hemoglobin content and decreased prothrombin time and white blood cells. Conclusion Among all the three test doses, ALME at 200 mg/kg have shown significant antioxidant effect and also exerts beneficial effect against cadmium induced hepatorenal toxicity.
Background Linagliptin is an antidiabetic drug used for the treatment of type-2 diabetes. The oral bioavailability of linagliptin is low (29.5%) due to its first pass metabolism in the intestine and liver. Gallic acid and ellagic acid are natural polyphenols which are widely distributed in fruits and medicinal plants. Gallic acid and ellagic acid have been reported to inhibit p-glycoprotein (p-gp) and enhance the bioavailability of p-gp substrate drugs. Hence, the purpose of the study was to evaluate the effect of gallic acid and ellagic acid on intestinal transport and bioavailability of linagliptin, a p-gp substrate in diabetic rats. Methods The intestinal transport of linagliptin was assessed by conducting an in situ single-pass intestinal perfusion study. The oral pharmacokinetics was evaluated by conducting oral bioavailability study in diabetic rats. Results After pretreatment with gallic acid and ellagic acid, no significant change in effective permeability of linagliptin was observed at the ileum part of the rat intestine. A significant improvement in the peak serum concentration (Cmax) and area under the serum concentration time profile (AUC), AUMC, AUCtotal and decrease in clearance were observed in rats pretreated with gallic acid and ellagic acid. Conclusions This study demonstrates that gallic acid and ellagic acids increase the bioavailability of oral linagliptin in rats due to the inhibition of p-gp. These animal data need to be confirmed in a clinical setting to determine whether linagliptin dosing should be adjusted when given concomitantly with these phytochemicals or gallic acid/ellagic acid-containing dietary supplements.
The present study was aimed to evaluate the root extract fractions of Kyllinga triceps (KT) for their antidiabetic potential on streptozotocin induced diabetes in neonatal rats. Diabetes was induced by a single intraperitoneal injection of Streptozotocin (90mg/kg) to 48±2h old neonatal rats. Effect of root extract fractions (toluene, ethyl acetate, 1-butanol at 50 &100 mg/kg.) were tested for their antihyperglycemic activity by measuring their fasting blood glucose level in diabetic rats at 0,2,4,6,8,12 & 24 h after the treatment. In sub acute study ethyl acetate fraction of KT (EAKT) was administered daily to diabetic rats orally at a dose of 100mg/kg for 28 days. Body weight of the animals and blood glucose level were observed at weekly interval during the study. Cholesterol, triglycerides, insulin, SGPT, ALP, creatinine and total proteins level in serum were also estimated at the initial and after 28 days of the treatment. As the preliminary investigation conducted in our lab on methanolic extract of the roots of KT had showed significant oral glucose tolerance with 200 mg/kg in normal rats. Oral administration of fractions of the plant significantly reduced the fasting blood glucose level in diabetic rats. Among the fractions, EAKT was found to be more effective. Further, in sub-acute study, EAKT, showed a significant anti diabetic activity by reversal of the altered afore said serum biochemical parameters. The results of the study are substantiating the traditional claim of the roots of Kyllinga triceps in the treatment of diabetes with a scope for development of antidiabetic herbal drug from EAKT.
Objective: The present study was aimed to investigate the protective effect of methanolic extract of the whole plant of Aerva monsoniae (MEAM) and selenium on cadmium (Cd)-induced oxidative liver damage in experimental rats. Methods:In the present study, albino Wistar rats were treated with Cd (5 mg/kg), selenium (1 mg/kg), and MEAM (250 and 500 mg/kg) for 21days. After 21 days of the treatment, the rats were sacrificed, and blood was collected for estimation of biochemical parameters and liver was used for histopathological studies.Results: Oral administration of Cd significantly elevated the levels of hepatic markers such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, cholesterol, total bilirubin, direct bilirubin, and decreased levels of total proteins and albumin. We also observed that elevated oxidative stress markers such as malondialdehyde reduced the enzymatic antioxidants such as superoxide dismutase, catalase, and non-enzymatic antioxidants such as reduced glutathione in the liver. Co-administration of MEAM and selenium in Cd-intoxicated rats, the altered biochemical parameters, and pathological changes were recovered significantly (p>0.01) than the individual effects of MEAM and selenium.Conclusion: From the above findings, it was concluded that combination of MEAM and selenium exhibited remarkable protective effects against Cdinduced oxidative liver damage in rats.
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