We have considered a tumor growth model with the effect of tumor-immune interaction and chemotherapeutic drug. We have considered two immune components-helper (resting) T-cells which stimulate CTLs and convert them into active (hunting) CTL cells and active (hunting) CTL cells which attack, destroy, or ingest the tumor cells. In our model there are four compartments, namely, tumor cells, active CTL cells, helper T-cells, and chemotherapeutic drug. We have discussed the behaviour of the solutions of our system. The dynamical behaviour of our system by analyzing the existence and stability of the system at various equilibrium points is discussed elaborately. We have set up an optimal control problem relative to the model so as to minimize the number of tumor cells and the chemotherapeutic drug administration. Here we used a quadratic control to quantify this goal and have considered the administration of chemotherapy drug as control to reduce the spread of the disease. The important mathematical findings for the dynamical behaviour of the tumor-immune model with control are also numerically verified using MATLAB. Finally, epidemiological implications of our analytical findings are addressed critically.
The low prevalence levels associated with lymphatic filariasis elimination pose a challenge for effective disease surveillance. As more countries achieve the World Health Organization criteria for halting mass treatment and move on to surveillance, there is increasing reliance on the utility of transmission assessment surveys (TAS) to measure success. However, the long-term disease outcomes after passing TAS are largely untested. Using 3 well-established mathematical models, we show that low-level prevalence can be maintained for a long period after halting mass treatment and that true elimination (0% prevalence) is usually slow to achieve. The risk of resurgence after achieving current targets is low and is hard to predict using just current prevalence. Although resurgence is often quick (<5 years), it can still occur outside of the currently recommended postintervention surveillance period of 4–6 years. Our results highlight the need for ongoing and enhanced postintervention monitoring, beyond the scope of TAS, to ensure sustained success.
In this paper, we have developed a compartment of epidemic model with vaccination. We have divided the total population into five classes, namely susceptible, exposed, infective, infective in treatment and recovered class. We have discussed about basic properties of the system and found the basic reproduction number (R0) of the system. The stability analysis of the model shows that the system is locally as well as globally asymptotically stable at disease-free equilibrium E0 when R0 < 1. When R0 > 1 endemic equilibrium E1 exists and the system becomes locally asymptotically stable at E1 under some conditions. We have also discussed the epidemic model with two controls, vaccination control and treatment control. An objective functional is considered which is based on a combination of minimizing the number of exposed and infective individuals and the cost of the vaccines and drugs dose. Then an optimal control pair is obtained which minimizes the objective functional. Our numerical findings are illustrated through computer simulations using MATLAB. Epidemiological implications of our analytical findings are addressed critically.
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