The first "In Water" imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained in high purity by filtration, resulting in a simple and scalable method.
Abstract2,5‐Dinitrofuran which can be easily prepared by nitration of 2‐nitrofuran, on phase transfer catalysed SNAr reaction with phenol gave good yield of 2‐aryloxy‐5‐nitrofuran. J. Heterocyclic Chem., (2011).
Preparation of 2-Aryloxy-5-nitrofuran. -This is the first example of a phase-transfer catalyzed SNAr reaction of 2,5-dinitrofuran. PEG gives similar results as the more expensive 18-crown-6. -(GAVADE, S.; PADIYA, K.; BAJARE, S.; BALASKAR, R.; MANE*, D.; J. Heterocycl. Chem. 48 (2011) 2, 458-462, http://dx.
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.
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