The Ru(ii)-catalyzed C-H activation and annulation reaction of salicylaldehydes and disubstituted alkynes affords chromones in high yields. This reaction also works with terminal alkynes and tolerates a wide range of sensitive functional groups. The selectivity pattern of this Ru(ii)-catalyzed annulation reaction is different from the known Au(i), Rh(iii)-catalyzed annulation reactions of salicylaldehydes and terminal alkynes.
An
unprecedented Pd(II)-catalyzed decarbonylative C–H/C–C
activation and annulation reaction, which proceeds via intramolecular
cyclization, is reported. This reaction of hydroxynaphthoquinones
with disubstituted alkynes provides good yields of substituted alkylidene
phthalides, which are the key intermediates for the synthesis of bioactive
natural products.
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