This finding opens an intriguing possibility of intranuclear delivery by merely tailoring the size of polymeric carriers, thus promising a new approach for cancer therapies.
elastic theory is general and may be used for the analysis of membranemediated interactions of the inclusions of different nature: transmembrane molecules, amphipathic peptides, etc. The work was supported by the Russian Foundation for Basic Organic fluorophores, such as Cy3 and Cy5, have been widely used as chemical labels to probe dynamics and functions of membrane proteins. While several water-soluble fluorophores have been reported interacting strongly with membrane lipid, detailed fluorophore-lipid interactions and the effect of fluorescent labeling on the natural dynamics of target proteins has not been revealed by experiment. We employed the highly mobile membrane mimetic (HMMM) model in a large set of all-atom molecular dynamics simulations to unravel the spontaneous partitioning of sulfo-Cy3/Cy5 fluorophores into lipid bilayers with different lipid compositions. Spontaneous membrane partitioning of Cy3/ Cy5 captured in these simulations reveals two steps. Electrostatic interaction 1401-Pos Board B310
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