Objective:To evaluate and compare the effects on high-sensitivity C-reactive protein (hs-CRP) levels and lipid profile of atorvastatin and rosuvastatin in obese type 2 diabetes mellitus (T2DM) patients.Materials and Methods:A total of 40 subjects with 20 in each group were randomly allocated to two groups. Group 1 patients received atorvastatin and that of Group 2 rosuvastatin treatment for 6 months. The patients were administered atorvastatin (40-80 mg) and rosuvastatin(10-40 mg) in accordance to their LDL-C status as per NCEP-ATP III guidelines. The parameters studied were, hs-CRP and lipid profile comprising LDL-C, HDL-C, TG and TC.Results:Results obtained from the study, clearly indicate that atorvastatin (A) as well as rosuvastatin(R) have significant effect on lowering of hs-CRP levels (for A P=0.001; for R P=0.002), reducing LDL-C levels (for A P=0.008; for R P=0.001), elevating HDL-C levels (for A P=0.02; for R P=0.001) along with reducing TC (for A P=0.003; for R P=0.002) and TG (for A P=0.000; for R P=0.000) levels in obese T2DM patients. It is also seen that there is no significant (P>0.05) difference in effect of atorvastatin and rosuvastatin in lowering of hs-CRP levels, elevating HDL-C levels and reducing TG levels in obese T2DM patients. However, percentage lowering of LDL-C (P=0.000) and TC (P=0.001) by rosuvastatin is to a greater extent than that caused by atorvastatin in these patients.Conclusions:Thus this study throws light on the fact that rosuvastatin should be preferred over atorvastatin in obese T2DM patients in whom LDL-C and TC levels are deviated from normal reference values. In rest of obese T2DM either of atorvastatin or rosuvastatin can be employed to lower hs-CRP levels, to elevate HDL-C levels or to reduce TG levels.
Background: The present study was carried out to evaluate the antidyslipidemic activities of seed extract of acacia tortilis (ATE) in alloxan inducd diabetic rats. Methods: The Rats were divided into five groups of six animals each. Groups I and II received normal saline, group III received ATE in dose of 100 mg/kg body weight, group IV received ATE in dose of 200 mg/kg b.w.; and group V received standard drug pioglitazone dose 3 mg/kg b.w. Drugs were administered orally once a day for 30 days. At the end of 0 th , 10 th , 20 th and 30 th day, blood was collected to analyse serum glucose, serum insulin, total cholesterol (TC), serum phospholipid (PL), serum triglyceride (TG), Free fatty acids (FFA) and High density lipoprotein (HDL).
Results:The results has been showed that ATE in above doses significantly increase the serum insulin and HDL level but significantly decreased the elevated level of TC, PL, TG , FFA, LDL and VLDL. It also decreased the atherogenic index and coronary risk index level significantly which was comparable with the pioglitazone. Conclusions: It is concluded that the seed extract of acacia tortilis at the dose of 100 and 200 mg/kg body weight produced significant anti-dyslipidemic activity in alloxan-induced diabetic rats.
for treating a new clinical condition takes time and consumes a lot of investment. Therefore, there is much attention given towards repurposing of old drugs for new therapy. Majority of drugs approved by FDA for a particular treatment has found applications in the treatment of various other clinical conditions too. In other words, it can be said as ‘reusing’ of a drug. This mini review focused on the use of repurposed drugs for bacterial infections and cancer treatment. Apart from the benefits of repurposing of drugs, there are some challenges needed to be addressed. Therefore, in this review paper the use of repurposed drugs in treatment of communicable (bacterial infections) and non-communicable (cancer) diseases were discussed.
Bangladesh Journal of Medical Science Vol.19(3) 2020 p.365-371
Poly cystic ovarian syndrome is a hormonal disorder common among women of reproductive age. Women with PCOD may have infrequent or prolonged menstrual periods or excess male hormone levels. This hormone imbalances cause them to skip menstrual periods and leads to infertility. The study is attempted to assess the knowledge and attitude regarding PCOD among adolescent girls in selected higher secondary schools. The research design of the study was non experimental descriptive survey design. Study was conducted among 60 adolescent girls in selected higher secondary schools at Trivandrum. The result shows that 88.33 percent of adolescent girls have less adequate knowledge regarding PCOD and only 11.67 percent have moderately adequate knowledge and 75 percent of samples have neutral attitude, 25 percent have negative attitude and no one have positive attitude regarding PCOD. The correlation shows moderately positive correlation between knowledge and attitude. The above findings shows that adolescent girls having less adequate knowledge and negative attitude regarding PCOD, so it is important to develop a self instructional module regarding PCOD for an education program.
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