Objective To investigate the occurrence rate and risk factors of postoperative nausea and vomiting (PONV) in lung cancer patients following lobectomy and application of analgesic pumps. Methods This retrospective study reviewed clinical data from patients that had undergone lobectomy for lung cancer under general anaesthesia. The risk factors of PONV were analysed using binary logistic regression models. Results A total of 203 patients (97 females) were enrolled. The rate of PONV was 29.6% (60 of 203 patients) for all patients, 42.3% (41 of 97 patients) for female patients and 17.9% (19 of 106 patients) for male patients. Female patients undergoing thoracotomy (odds ratio [OR] 7.770, 95% confidence interval [CI] 1.747, 34.568) or having surgery durations ≥120 min (OR 4.493, 95% CI 1.502, 12.851) were significantly more susceptible to PONV. The risk of PONV in female patients that received postoperative dolasetron (100 mg, once a day) was significantly lower (OR 0.075, 95% CI 0.007, 0.834). For male patients, the risk of PONV was significantly lower in those with a body mass index ≥24 kg/m2 (OR 0.166; 95% CI 0.035, 0.782). Conclusion Female and male patients have different risk factors for PONV following lobectomy for lung cancer and application of analgesic pumps.
Background: Radio-induced brain necrosis is a late-onset radiotherapy complication, especially in nasopharyngeal carcinoma (NPC) patients. We presented the clinicopathological characteristics, dynamic changes of MRI features, and radiation dose in the areas of radio-induced brain necrosis, which will shed light on preventing this severe radiotherapy complication. Methods: We retrospectively collecting and reanalyzing clinical, imaging, radiation plans and pathological data from 48 NPC patients diagnosed with radio-induced brain necrosis and underwent craniotomy. To calculate the radiation dose in the areas of radio-induced brain necrosis, we reviewed the radiation plan of each patient and delineated the volume of the radio-induced brain necrosis. We also mapped the dynamic changes of magnetic resonance imaging (MRI) features and performed CD3, CD31, CD68, CD11b, Ki67, terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) and HE staining on radio-induced brain necrosis specimens to observe pathological changes. Results: The mean latency period for radio-induced brain necrosis was 9.23 years. According to the radiotherapy plans, the mean radiation dose for NPC was 7041±553 cGy. The mean dose to the radio-induced brain necrosis area was 5684.57±409.99 cGy. The necrotic areas exhibited high-intensity signals on T2-weighted images (WIs) and low-intensity signals on T1WIs over time. HE staining showed that the necrotic areas contained irregular fibers and inflammatory cells. The immunohistochemical results showed CD3(+), CD31(+), CD68(+), CD11b(+), Ki67(+), and TUNEL(+) cells in radio-induced brain necrosis specimens. Conclusions: NPC patients who underwent radiotherapy and survived more than 5 years with hyperintense signals in temporal lobes in the T2WI should be paid close attention to radio-induced brain necrosis. A radiation dose no more than 5684.57±409.99 cGy in temporal lobes of NPC patients is recommended.
Background: Radio-induced brain necrosis is a late-onset radiotherapy complication, especially in nasopharyngeal carcinoma (NPC) patients. We presented the clinicopathological characteristics, dynamic changes of MRI features, and radiation dose in the areas of radio-induced brain necrosis, which will shed light on preventing this severe radiotherapy complication. Methods: We retrospectively collecting and reanalyzing clinical, imaging, radiation plans and pathological data from 48 NPC patients diagnosed with radio-induced brain necrosis and underwent craniotomy. To calculate the radiation dose in the areas of radio-induced brain necrosis, we reviewed the radiation plan of each patient and delineated the volume of the radio-induced brain necrosis. We also mapped the dynamic changes of magnetic resonance imaging (MRI) features and performed CD3, CD31, CD68, CD11b, Ki67, terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) and HE staining on radio-induced brain necrosis specimens to observe pathological changes. Results: The mean latency period for radio-induced brain necrosis was 9.23 years. According to the radiotherapy plans, the mean radiation dose for NPC was 7041±553 cGy. The mean dose to the radio-induced brain necrosis area was 5684.57±409.99 cGy. The necrotic areas exhibited high-intensity signals on T2-weighted images (WIs) and low-intensity signals on T1WIs over time. HE staining showed that the necrotic areas contained irregular fibers and inflammatory cells. The immunohistochemical results showed CD3(+), CD31(+), CD68(+), CD11b(+), Ki67(+), and TUNEL(+) cells in radio-induced brain necrosis specimens. Conclusions: NPC patients who underwent radiotherapy and survived more than 5 years with hyperintense signals in temporal lobes in the T2WI should be paid close attention to radio-induced brain necrosis. A radiation dose no more than 5684.57±409.99 cGy in temporal lobes of NPC patients is recommended.
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