Although recurrent malignancy is the most frequent indication for second stem cell transplantation (2nd SCT), there are few reports that include sufficiently large numbers of patients to enable prognostic factor analysis. This retrospective study includes 150 patients who underwent a 2nd SCT for relapsed acute myeloblastic leukaemia (n = 61), acute lymphoblastic leukaemia (n = 47) or chronic myeloid leukaemia (n = 42) after a first allogeneic transplant (including 26 T‐cell‐depleted). The median interval between the first transplant and relapse, and between relapse and second transplant was 17 months and 5 months respectively. After the 2nd SCT, engraftment occurred in 93% of cases, 32% of patients developed acute graft‐vs.‐host disease (GVHD)  grade II and 38% chronic GVHD. The 5‐year overall and disease‐free survival were 32 ± 8% and 30 ± 8%, respectively, with a risk of relapse of 44 ± 12% and a transplant‐related mortality of 45 ± 9%. In a multivariate analysis, five factors were associated with a better outcome after 2nd SCT: age < 16 years at second transplant; relapse occurring more than 12 months after the first transplant; transplantation from a female donor; absence of acute GVHD; and the occurrence of chronic GVHD. The best candidates for a second transplant are likely to be patients with acute leukaemia in remission before transplant, in whom the HLA‐identical donor was female and who relapsed more than 1 year after the first transplant.

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Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low-or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergency abdominal surgery, comparing findings across countries with a low, middle or high Human Development Index (HDI).Methods: This was a prospective, multicentre, cohort study. Self-selected hospitals performing emergency surgery submitted prespecified data for consecutive patients from at least one 2-week interval during July to December 2014. Postoperative mortality was analysed by hierarchical multivariable logistic regression.

Deep inelastic scattering and its diffractive component, ep -> e'y*p -> e'XN, have been studied at HERA with the ZEUS detector using an integrated luminosity of 4.2 pb(-1). The measurement covers a wide range in the y*p c.m. energy W (37-245 GeV), photon virtuality Q(2) (2.2-80 GeV(2)) and mass M(X) (0.28-35 GeV). The diffractive cross section for M(X) > 2 GeV rises strongly with W; the rise is steeper with increasing Q(2). The latter observation excludes the description of diffraclive deep inelastic scattering in terms of the exchange of a single pomeron. The ratio of diffractive to total cross section is constant as a function of W, in contradiction to the expectation of Regge phenomenology combined with a naive extension of the optical theorem to y*p scattering. Above M(X) of 8 GeV, the ratio is flat with Q(2), indicating a leading-twist behaviour of the diffractive cross section. The data are also presented in terms of the diffractive structure function, F(2)(D(3)) (beta, x(P), Q(2)) of the proton. For fixed beta, the Q(2) dependence of x(P)F2(D)((3)) changes with x(P) in violation of Regge factorisation. For fixed xp, x(P,) x(P)F(2)(D(3)) rises as beta -> 0, the rise accelerating with increasing Q(2). These positive scaling violations suggest substantial contributions of perturbative effects in the diffractive DIS cross section. (c) 2005 Elsevier B.V. All rights reserved

A search for the decays of the Higgs and Z bosons to a ϕ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of 2.7  fb^{-1} collected at sqrt[s]=13  TeV with the ATLAS detector at the LHC. No significant excess of events is observed above the background, and 95% confidence level upper limits on the branching fractions of the Higgs and Z boson decays to ϕγ of 1.4×10^{-3} and 8.3×10^{-6}, respectively, are obtained.

Polychaete body fossils are rare, and are almost invariably compressed and too poorly preserved for meaningful comparison with extant forms. We here describe Kenostrychus clementsi gen. et sp. nov. from the Silurian Herefordshire Konservat-LagerstÌtte of England, in which three-dimensional external morphology is preserved with a ¢delity unprecedented among fossil polychaetes. The fossils, which are preserved in calcite, were serially ground and photographed at 30 mm intervals to produce computergenerated reconstructions of the original external surface. The new genus has a generalized polychaete morphology with large biramous parapodia, unspecialized anterior segments and a small prostomium with median and lateral antennae and ventral prostomial palps. Cirriform branchiae arise from the ventral surface of each notopodium, and may be homologous with the inter-ramal branchiae of the extant nephtyids. Through cladistic analysis, Kenostrychus is interpreted as a member of a stem group of either the Phyllodocida or the Aciculata (Phyllodocida + Eunicida). Direct comparison with other fossil forms is di¤cult, but hints that inter-ramal respiratory structures may be primitive within the Phyllodocida and/ or the Aciculata.

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In deep inelastic neutral current scattering of positrons acid protons at the center of mass energy of 300 GeV, we observe, with the ZEUS detector, events with a high energy neutron produced at very small scattering angles with respect to the proton direction. The events constitute a fixed fraction of the deep inelastic, neutral current event sample independent of Bjorken x and Q(2) in the range 3 . 10(-4)