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OBJECTIVE: The distribution and biological roles of interleukin (IL)-1␤, IL-6, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the synovial fluid of patients with non-inflammatory chronic temporomandibular joint (TMJ) disorders were evaluated in relation to pain upon joint movements and X-ray and magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS: TMJ aspirates were obtained from 48 patients (48 joints) with chronic TMJ disorders and from 18 controls (18 joints). The IL-1␤ and IL-6 levels in the aspirates were determined by using an enzyme-linked immunosorbent assay and the TIMP-1 level was measured by an enzyme immunoassay. Following examinations for pain upon joint movements and Xray and MRI observations, the IL-1␤, IL-6, and TIMP-1 levels and frequencies of their detection were compared. RESULTS: The IL-1␤ level and frequency of detection showed no correlation with pain upon joint movements or with the X-ray and MRI findings. In the frequency of detection of IL-6, there were significant differences between control (no detection) and all chronic TMJ disorder groups that were classified by imaging diagnosis (P Ͻ 0.001). A correlation was also noted between the presence of IL-6 and pain upon joint movements. The IL-6 level was correlated with the TIMP-1 level and with pain upon joint movements. TIMP-1 level was correlated with pain upon joint movements. The TIMP-1 was present in higher level from patients with chronic TMJ disorders who exhibited osseous changes on the X-ray images. CONCLUSION: The results indicated that the IL-6 and TIMP-1 levels in the TMJ aspirates of patients with chronic TMJ disorders have been raised. The former was not detected in the TMJ aspirates of the control. These findings suggest that IL-6 and TIMP-1 might play a role Correspondence: Chisei Shinoda, in the etiology of chronic TMJ disorders, but further studies are needed to validate this. Oral Diseases (2000) 6, 383-390 Keywords: interleukin; tissue inhibitor of metalloproteinase-1; biochemical analysis; synovial fluid; temporomandibular joint IL-1␤, IL-6 and TIMP-1 in the synovial fluid of the TMJ C Shinoda and S Takaku

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