This study reports a cobalt-catalyzed synthesis of cyclobutenes using alkynes and acrylates bearing a leaving group at the α position. The cyclobutene formation was facilitated by an appropriate proton source. In the presence of a Lewis acid, acetonitrile participated in the reaction, affording the corresponding functionalized cyclobutenes.[a] Prof.
Cyclobutene Ring! A cobalt complex with dppf as the ligand catalyzed the synthesis of cyclobutenes from alkynes and acrylates bearing a leaving group at the α position. The formation of cyclobutenes was facilitated by a suitable proton source. In the presence of a Lewis acid, acetonitrile participated in the reaction, affording the corresponding acetylated cyclobutenes. More information can be found in the Communication by Tetsuaki Fujihara, Yasushi Tsuji et al. on page 2456 in Issue 12, 2018 (DOI: 10.1002/ajoc.201800561).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.