Aims and objectives: This study aimed to establish and test a predictive model for explaining the health-related quality of life of young adult patients with stroke. Background: Individual characteristics, biological and physiological variables, social support, emotional and cognitive symptoms, physical function disability and general health perception may be interrelated and may directly or indirectly affect the healthrelated quality of life of young adult patients with stroke. Design: A cross-sectional study. Methods: 237 young outpatients with stroke were recruited and surveyed. Data collection used a structured questionnaire from July-November 2018. The collected data were analysed using SPSS version 25.0 ® and AMOS 23.0. This study is based on STROBE guidelines. Results: The hypothetical model's fit indices were adequate. Stroke severity, social support, fear of stroke recurrence, physical function disability and general health perceptions directly affected the health-related quality of life. Additionally, stroke severity, depression and fear of stroke recurrence also indirectly affected it. These variables explained 60.3% of the variance in this quality.Conclusions: Variables such as severity of stroke, depression, fear of stroke recurrence, social support, physical function disability and general health perception were found to be related to the HRQoL of young adult patients with stroke.Relevance to clinical practice: A variety of physical, psychological, functional and social factors related to health-related quality of life should be systematically monitored. Furthermore, nurses need to develop and apply detailed nursing interventions that take into account all these variables.
Purpose The aim of this study was to assess the reliability and validity of the Korean short version of the Stroke-Specific Quality of Life Scale (SS-QoL-12K). Design A descriptive, cross-sectional design was used. Methods We recruited 233 outpatients with ischemic stroke. Findings The Cronbach’s alpha coefficients for internal consistency was .93, and the test–retest reliability value was .98. Confirmatory factor analysis identified two dimensions for the SS-QoL-12K. The SS-QoL-12K was correlated positively with the 36-Item Short Form Health Survey score and Instrumental Activities of Daily Living and negatively with the modified Rankin Scale score. The SS-QoL scores in the National Institutes of Health Stroke Scale mild group were higher than those in the National Institutes of Health Stroke Scale moderate and severe groups. Conclusions This study shows that the SS-QoL-12K has a satisfactory level of reliability and validity in patients with ischemic stroke. Clinical Relevance This instrument will be helpful in advancing research and clinical care for stroke patients.
In the study here, the potential applicability of KMRC011-an agonist of toll-like receptor-5as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose ¼ 7 Gy) of Co 60 c-rays, mortality rates and degrees of pathological lesions that developed over 80 days were compared in monkeys that received TBI only and a group that was injected once with KMRC011 (10 lg/kg) after TBI. Compared to the TBI-only hosts (80%), the death rate was significantly improved by the use of KMRC011 (40%), all deaths in both groups occurred in the period from Days 19-24 post-TBI. Further analysis of monkeys that survived until the end of the experiment showed that AST and ALT levels were elevated only in the TBI group, and that radiation-induced tissue damage was alleviated by the KMRC011 injection. Additionally, expression of cell death-related proteins was lower in tissues from the KMRC011-treated hosts than in those in the TBI-only group. Other measured parameters, including body weight, food uptake, and hematological values did not significantly differ between the two groups over the entire period. The results of this study, thus demonstrate that KMRC011 could potentially be used as a medical countermeasure for the treatment of acute radiation exposure.
The purpose of this study was to investigate the awareness of the necessity and importance of liberal arts education and to examine the satisfaction of college students with their liberal arts courses. This study was conducted from June 1–15, 2018, for college students who are taking liberal arts courses. The collected data were analyzed using the SPSS 24.0 and AMOS 24.0 statistical package programs. To understand the general characteristics of the survey subjects, a frequency analysis, exploratory factor analysis, correlation analysis, and reliability analysis were performed to measure the reliability and validity of the measurement tools, and a structural model analysis was conducted to verify the proposed research model. The result shows that a professor’s professionalism has a positive influence on the perception of a subject’s importance and necessity after the course, diversity has a positive influence on satisfaction in liberal arts education. Favorable changes in the perception of importance and necessity have a positive effect on satisfaction level. Our findings imply that colleges should operate an integrated student-selective education course that allows all students to select and take liberal arts courses. It should be organized to secure full-time professors who will be exclusively responsible for liberal arts curriculums.
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