Four new isomeric macrolides of combretastatin D-2 congeners named isocorniculatolide A (1), 11-O-methylisocorniculatolide A (2), 11-O-methylcorniculatolide A (3), and 12-hydroxy-11-O-methylcorniculatolide A (4), and the known corniculatolide A (5), arjunolic acid, and maslinic acid were isolated from the CHCl(3) extract of the bark of Aegiceras corniculatum. The structures of the new compounds (1-4) were elucidated by a combination of spectroscopic analysis (1-5), chemical modifications, and single-crystal X-ray analysis (1).
Two new constitutional isomers of ent‐labdane‐type diterpenoids, 1 and 2, with an unusual seven‐membered lactone moiety (i.e., 1), together with two known compounds, 3 and 4, were isolated from the acetone extract of Rhizophora mucronata. Their structures were elucidated as rhizomucronol A and B (1 and 2, resp.) by spectroscopic analyses and chemical evidence. The absolute configuration of 2 was established by applying the Mosher ester procedure.
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