Dumbbells that block: Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S‐adenosylmethionine, Fl=Cy3 fluorescence label, CN=5‐azadC, C‐Me=5‐methyldC).
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