1,1-Dibromo-1-alkenes were coupled with a variety of aryl boronic acids using Suzuki conditions (PdCl 2 (PPh 3 ) 2 /Na 2 CO 3 / THF-H 2 O or DME-H 2 O/65-90°C). The 1,1-dibromo-1-alkenes were prepared from ketones, and thus, the overall process furnished tetra-substituted alkenes in a very efficient manner.
Pyrimidine derivativesPyrimidine derivatives R 0510 Oximino-Piperidino-Piperidine-Based CCR5 Antagonists. Part 2. Synthesis, SAR and Biological Evaluation of Symmetrical Heteroaryl Carboxamides. -A series of potent and bioavailable CCR5 antagonists with enhanced affinity for the CCR5 receptor are generated. Compounds with small O-alkyl substituents on the oxime, e.g. (XIVa) are optimal (some yields not given). -(PALANI*, A.; SHAPIRO, S.; CLADER, J. W.; GREENLEE, W. J.; VICE, S.; MCCOMBIE, S.; COX, K.; STRIZKI, J.; BAROUDY, B. M.; Bioorg. Med. Chem. Lett. 13 (2003) 4, 709-712; Dep. Chem. Res., Schering-Plough Res. Inst., Kenilworth, NJ 07033, USA; Eng.) -M. Schroeter 25-165
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.