Some cases of porphyria cutanea tarda have been associated with the ttse of the organochlorine insecticide lindane and the organophosphorous insecticide diazinon. In the case of diazinon, an impurity is the active agent. This impurity has been identified as an isomer of diazinon and is designated isodiazinon. In rats treated with diazinon and isodiazirion, increased faecal excretion of porphyrins was seen only in animals treated with both compounds. In these animals the enzyme ferrochelatase was significantly inhibited. It is suggested that porphyria cutanea tarda only arises on exposure to these agents in persons with a pre-existing deficiency of uroporphyrinogen decarboxylase.
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