The apolipoprotein (APOE) ε4 allele is associated with cognitive deficits and hippocampal atrophy in nondemented middle-aged and older adults. It is not known to what extent this genetic risk factor for Alzheimer's disease (AD) impacts performance in late middle-aged and older workers in cognitively demanding occupations. This cross-sectional analysis examines brain–cognitive–genetic relationships in actively flying general aviation pilots, half of whom are APOE ε4 carriers. Fifty pilots were studied with structural MRI and memory tasks. Average visual paired associate memory recall performance was lower in APOE ε4 carriers than non-carriers. Memory performance correlated positively with hippocampal volume, but no structural differences were found in hippocampal or frontal volumes with respect to APOE ε4 allele. These results were evident in healthy professionals without any presenting memory problems and without selection for a family history of AD. These findings point to basic memory testing as a sensitive tool for detecting APOE ε4 -related influences on memory in aging workers.

This research develops, trials and evaluates three innovative game apps on mobile touch screen technology that addresses the needs of older adults during activity groups. The research was conducted with a group of older adults participating in the ageing-well activity program of a local council. The project assists older adults to discover and to increase their technology use in a familiar group setting. Building on established interests such as family history, cooking and movies, the study investigates how mobile technology can further these activity groups. The project aims to explore how mobile technology can be integrated in group settings (1) and to develop games suitable for these different settings (2). The paper makes recommendations for game play in older adults' activity groups using touch tablets.