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Fused pyrimidine derivatives R 0515 Synthesis and SAR of 2-Aryl Pyrido[2,3-d]pyrimidines as Potent mGlu5 Receptor Antagonists. -The synthesis and the pharmacological activities of this promising new class of mGlu5 receptor antagonists are discussed. The in vivo activity of derivative (IVb) is comparable to that of rafecoxib in the rat MIA model of osteoarthritis pain. -(WENDT*, J. A.; DEETER, S. D.; BOVE, S. E.; KNAUER, C. S.; BROOKER, R. M.; AUGELLI-SZAFRAN, C. E.; SCHWARZ, R. D.; KINSORA, J. J.; KILGORE, K. S.; Bioorg. Med.