The introduction of a tertiary amino substituent into urethane-type protecting groups [as in ( l ) , (4), (8) and (12)] increases their acid-stability and provides a 'handle' for the facilitation of peptide synthesis ; analogues of t-butoxycarbonyl and benzyloxycarbonyl groups having NN-dimethylcarbamoyl substituents [(15) and (IS)], designed to increase the solubility of protected peptides in dimethylformamide, are also reported.
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