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; Judith A Smith -j.a.smith@lancaster.ac.uk; Alison J Lee -a.j.lee@leeds.ac.uk; R Elwyn Isaac -r.e.isaac@leeds.ac.uk; Alan D Shirras* -a.shirras@lancaster.ac.uk * Corresponding author AbstractBackground: Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes. As more invertebrate genomes are sequenced, there is increasing evidence of a variety of M2 peptidase genes, even within a single species. The function of these ACE-like proteins is largely unknown. Sequencing of the A. gambiae genome has revealed a number of ACE-like genes but probable errors in the Ensembl annotation have left the number of ACE-like genes, and their structure, unclear.