In patients with thin melanomas, MR >0 seems to be a significant predictor of SLN positivity that may be used to risk-stratify and select patients for LM/SL. To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients.

No abstract

Neither the use of BV nor timing of BV administration was associated with an increase in complication rates. These data suggest that the combination of BV with neoadjuvant CTX in patients who have CRC liver metastases does not increase surgical complications. To determine the optimal timing of surgery in patients receiving neoadjuvant BV, confirmatory prospective studies are required.

Highlights d Menopause, obesity, and cancer increase pro-inflammatory cytokines in human breast fat d Estrone stimulates and estradiol relieves the inflammation of obesity in vivo d Estrone cooperates with NFkB to induce inflammatory mediators, but estradiol does not d HSD17B14 increases intracellular estrone to drive inflammation and ER+ CSC expansion