The mechanism of the chromic acid cooxidation of 2-hydroxy-2-methylbutyric acid (HMBA) and 2-propanol (ROH) was investigated by using deuterium and carbon-13 isotope effects. The carbon isotope effect associated with the oxidative decarboxylation of HMBA was determined from the mass ratio 44:45 (12C02:13C02), the deuterium isotope effect from kinetic measurements. When the acidity is increased from [H+] = 0.02 or 0.05 M to [H+] = 1.86 M, the deuterium isotope effect,

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