The Clauson-Kaas pyrrole synthesis involving the reaction of primary amines with 2,5-dialkoxytetrahydrofurans is traditionally carried out in refluxing acetic acid (AcOH), whereas extension to less activated nitrogen nucleophiles often necessitates the use of acidic promoters. It is now reported that the preparation of N-substituted pyrroles can be effected under microwave conditions (10 min -30 min) using acetic acid or water without additional catalysts.
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