Product development of ophthalmic preparations has received considerable attention in the last few years. With the increasing emphasis on their sterility, some of the differences between them and parenteral preparations are becoming less evident. Both classes of preparations employ similar added substances and manufacturing procedures. The successful formulation of poorly water-soluble drugs is one of the major problems in pharmaceutical manufacturing. Poorly water-soluble drugs, such as indomethacin, may show low and erratic oral bioavailability due to poor dissolution of the drug in the fluids of the gastrointestinal tract. Indomethacin is a water insoluble drug, so problems of formulating an aqueous eye-drop are well known. Moreover, unstability of Indomethacin aqueous preparations is also a great challenge. In this research work, considering pharmacological importance of drug Indomethacin, we tried to overcome the problem of poor water solubility by making a salt of it and thus formulating an aqueous ophthalmic preparation.
The plant Butea monosperma is very popular among the peoples of Northern Ghana, where the leaves are used in soups; and calyces for soft drinks and also used medicinally. It has been found to possess several health benefits. The flower has a very rich orange colour, which this study aims as investigating its suitability as a coloring agent in pharmaceutical syrup. Materials and Methods:The plant parts (flowers) are used in experimental work for investigating the suitability of Butea monosperma extract as coloring agent for pediatric syrup. 1kg of dried Butea Monosperma flowers were weighed out and spread out in a thin layer. After authentication, sample of Butea monosperma was washed for ten seconds in water (to avoid losing colour). Excess water was blotted from the sample with a clean towel, and dried in a hot air oven for four hours at 300ºC before the extraction procedure. Then the solvent for extraction (water, drug solvent ratio taken = 1:8) was filled in Soxhlet apparatus. After completion of the extraction procedure, the extract was taken out and evaporated up to semisolid consistency and then amount in percentages was determined in % w/w. Result:The colour extract from Butea monosperma is found suitable as a pharmaceutical coloring agent. Tartrazine can be replaced with this natural source of colour, promoting the health of our people.
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