No abstract

No abstract

No abstract

No abstract

In late 2009, Amazon introduced spot instances to offer their unused resources at lower cost with reduced reliability. Amazon's spot instances allow customers to bid on unused Amazon EC2 capacity and run those instances for as long as their bid exceeds the current spot price. The spot price changes periodically based on supply and demand, and customers whose bids exceed it gain access to the available spot instances. Customers may expect their services at lower cost with spot instances compared to on-demand or reserved. However the reliability is compromised since the instances(IaaS) providing the service(SaaS) may become unavailable at any time without any notice to the customer. Checkpointing and migration schemes are of great use to cope with such situation. In this paper we study various checkpointing schemes that can be used with spot instances. Also we device some algorithms for checkpointing scheme on top of application-centric resource provisioning framework that increase the reliability while reducing the cost significantly.

No abstract

The recent discovery of long non-coding RNA as a regulatory molecule in the cellular system has altered the concept of the functional aptitude of the genome. Since our publication of the first version of LncRBase in 2014, there has been an enormous increase in the number of annotated lncRNAs of multiple species other than Human and Mouse. LncRBase V.2 hosts information of 549,648 lncRNAs corresponding to six additional species besides Human and Mouse, viz. Rat, Fruitfly, Zebrafish, Chicken, Cow and C. elegans. It provides additional distinct features such as (i) Transcription Factor Binding Site (TFBS) in the lncRNA promoter region, (ii) sub-cellular localization pattern of lncRNAs (iii) lnc-pri-miRNAs (iv) Possible small open reading frames (sORFs) within lncRNA. (v) Manually curated information of interacting target molecules and disease association of lncRNA genes (vi) Distribution of lncRNAs across multiple tissues of all species. Moreover, we have hosted ClinicLSNP within LncRBase V.2. ClinicLSNP has a comprehensive catalogue of lncRNA variants present within breast, ovarian, and cervical cancer inferred from 561 RNA-Seq data corresponding to these cancers. Further, we have checked whether these lncRNA variants overlap with (i)Repeat elements,(ii)CGI, (iii)TFBS within lncRNA loci (iv)SNP localization in trait-associated Linkage Disequilibrium(LD) region, (v)predicted the potentially pathogenic variants and (vi)effect of SNP on lncRNA secondary structure. Overall, LncRBaseV.2 is a user-friendly database to survey, search and retrieve information about multi-species lncRNAs. Further, ClinicLSNP will serve as a useful resource for cancer specific lncRNA variants and their related information. The database is freely accessible and available at http://dibresources.jcbose.ac.in/zhumur/lncrbase2/.

In recent years most of the cloud computing community adopt an infrastructure centric approach to optimize the cost of cloud resources considering both Cloud Computing Service Users(CCSU) and Cloud Computing Service Providers(CCSP). In this paper we have brought up the concept of Applicationcentric Cloud.With Application-centric Cloud we propose an architecture to provide a generalized framework for auto deploying, sharing, providing scalability, robustness and availability of any cloud based application. Along with application independence, the framework also considers CCSP independence so that an application can use resources across providers.