In the present manuscript, the facile synthesis of tri-Schiff's bases, containing the core-thiophosphate moiety by using O,O,O-tris(4-formylphenyl) phosphorothioate, 3 and substituted anilines as a precursor has been reported. The key precursor 3 has been prepared under mild conditions in presence of (C4H9)4NBr as a phase transfer catalyst. All the synthesized compounds (5a-5h) were screened for their antibacterial and antifungal activities and were found to show good to excellent antibacterial and antifungal activities as compared to the standards.
Facile synthesis of various organophosphorus trichalcones, possessing substantial insecticidal activity, by using tris(4-acetylphenyl)-phosphate (3) and substituted benzaldehydes as a precursor has been reported. Key precursor 3 has been prepared under mild conditions in presence of tetrabutylammonium bromide (TBAB) as a phase transfer catalyst. All the synthesized compounds (5a-h) were screened for their antibacterial activity and inhibition of α-amylase of insect pest, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionadeae). Biological activity evaluation study revealed that among all the compounds screened, compound 5g found to have promising inhibition of α-amylase of insect pest, Tribolium castaneum. All the synthesized compounds revealed insignificant antimicrobial activity against pathogenic bacteria even at 500 μg/mL.
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