Follicular dendritic cell sarcoma (FDCS) most commonly involves lymph nodes but also affects extranodal sites like liver, spleen, pancreas less commonly. It is a low to intermediate grade malignancy. Unusual presentation, morphology or immunophenotyping makes the diagnosis of FDCS very challenging. Immunohistochemistry plays a major role in confirming the diagnosis of FDCS. A 40 year male presented with dull abdominal pain. Ultrasonography revealed two hypoechoiec lesions in liver. Cytomorphology, later histological and immunohistochemistry (IHC) diagnosis of FDCS was established. Patient was put on chemotherapy.
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