We demonstrated modulation of the waveguide mode mismatch via liquid cladding of the controllable refractive index for label-free quantitative detection of concentration of chemical or biological substances. A multimode optical fiber with its core exposed was used as the sensor head with the suitable chemical modification of its surface. Injected analyte liquid itself formed the liquid cladding for the waveguide. We found that modulation of the concentration of analyte injected enables a degree of the waveguide mode mismatch to be controlled, resulting in sensitive change in optical power transmission, which was utilized for its real-time quantitative assay. We applied the device to quantitating concentration of glycerol and bovine serum albumin (BSA) solutions. We obtained experimentally the limit of detection (LOD) of glycerol concentration, 0.001% (volume ratio), corresponding to the resolvable index resolution of ∼1.02 × 10 RIU (refractive index unit). The presented sensors also exhibited reasonably good reproducibility. In BSA detection, the sensor device response was sensitive to change in the refractive indices not only of liquid bulk but also of layers just above the sensing surface with higher sensitivity, providing the LOD experimentally as ∼3.7 ng/mL (mass coverage of ∼30 pg/mm). A theoretical model was also presented to invoke both mode mismatch modulation and evanescent field absorption for understanding of the transmission change, offering a theoretical background for designing the sensor head structure for a given analyte. Interestingly, the device sensing length played little role in the important sensor characteristics such as sensitivity, unlike most of the waveguide-based sensors. This unraveled the possibility of realizing a highly simple structured label-free sensor for point-of-care testing in a real-time manner via an optical waveguide with liquid cladding. This required neither metal nor dielectric coating but still produced sensitivity comparable to those of other types of label-free sensors such as plasmonic fiber ones.
Planar Hall effect measurements were carried out on two GaMnAs ferromagnetic films with different Mn concentrations (6.2% and 8.3% Mn). The switching fields of magnetization taken from field scans of the planar Hall effect showed significantly different angular dependences in the two samples. While the angular dependence of the switching field for the sample with 8.3% Mn had a symmetric rectangular shape in the polar plot, that of the other sample with 6.2% Mn exhibited a clearly asymmetric behavior, with large steps at the 〈110〉 crystallographic directions. This switching field behavior was analyzed by considering pinning fields for crossing the 〈110〉 directions. The fitting of step features appearing at the 〈110〉 directions revealed the presence of a new uniaxial anisotropy field Hu2 along the [100] direction, in addition to the commonly observed cubic Hc anisotropy field (along the 〈100〉 directions) and uniaxial anisotropy Hu1 fields (along either the [110] or the [11¯0] direction) in the GaMnAs film.
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